How Beta 1,3/1,6 Glucan Nutritionally Fights Back Through the Immune Response Against Cancer and Aids in
Chemotherapy Effectiveness
What is Cancer and How Does It Attack the Body?
The second most common cause of death in the U.S. is cancer, accounting for 1 in 4 deaths in the year 2003. In
2003, according to the American Cancer Society, 1,334,100 new cancer cases or a 3.8% increase will occur with 556,500
deaths. That equates to three jet commercial aircraft carrying 1,500 people going down per day with all lost! 2.5+
per minute will be diagnosed with cancer with 1+ per minute dying. The most new cases for 2003 are estimated for
prostate cancer (220,900 new cases - 28,900 deaths). Next is Breast Cancer with 212,600 new cases and 40,200 deaths,
followed by Colorectal Cancer with 147,500 new cases and 57,100 deaths.
But what is cancer?
Cancer is any of a group of more than 100 diseases which symptoms are unrestrained growth of cells in one of the
body organs or tissues. The fact is you probably will get cancer up to six times during your life, but your immune
system when at peak destroys the cancerous cells before growth and multiplication! When not destroyed immediately
by your immune system, the cancer-invaded cells deviate from the usual controls over cell growth.
The growth begins when the genes controlling cell growth and multiplication (oncogenes) are transformed by cancer-causing
agents known as carcinogens. After a cell has a malignant transformation, the small group of abnormal cells divide
more rapidly than the normal surrounding cells. The abnormal cells usually show a lack of "differentiation,"
meaning they no longer perform the specialized task of their host tissue. Thus, the cancerous cells are in fact
parasites avoiding control of hormones and nerves and consuming nutrients while contributing nothing. This rapid
multiplication results in invasion and destruction of other body cells. These cancerous cells can then spread (metastasize)
via the bloodstream and lymphatic system to other parts of the body from their original site.
A cancer differs from a benign (non-dangerous) tumor in two ways: cancers grow, spread and infiltrate the tissues
around them, in addition to spreading to form new tumors that grow independently. Cancerous tumors develop and
multiply when the immune system surveillance team fails to identify the cancerous cell invaders and then is overwhelmed
when recognition does occur, due to the massive number of corrupted cancer cells that have multiplied rapidly when
undetected and unchecked. We are our own worst enemies in that we first suppress our immune systems with excessive
free radicals, or rogue molecules, that damage cells due to the impact of toxins on our systems. Polluted air,
water, fast food; in addition to pathogens such as parasites, fungi, bacteria and viruses joined with heavy metals
and toxic chemicals, assault us daily. Genetic factors join immunological weakness in certain cancer cases.
Cancer Treatments
The most common treatment in 50% of cases is chemotherapy, but success occurs in only a few cases (2 to 25%), such
as ovarian cancer in women and testicular cancer in men, in addition to Duke's C, a form of colon cancer. The logical
question to ask would be, if chemotherapy has such a low rate of success, why is it used so often? Dr. Ralph Moss,
author of Questioning Chemotherapy, explains that most people confuse decreased tumor size with disappearance of
disease. The association appears logical, but no known proof exists to support the connection.
Fractionated chemotherapy is gaining acceptance, including at Cancer Treatment Centers of America, and involves
spacing smaller amounts of chemotherapy drugs over more treatments in an extended period of time. The theory is
to allow the body more time to recover from the poison effects in essential functions excepting the killing of
the cancer cells. Results appear to be positive.
It is troubling that alternative therapies are often criticized for not being tested according to scientific standards,
but many "accepted" treatments, including chemotherapy, have only limited success and little correlation
between tumor shrinkage and patient survival. The answer unfortunately often appears to be economics, with chemotherapy
treatments frequently costing six figures. We must understand the facts, which are often difficult to accept in
the midst of such suffering and fear for life caused by these dreaded cancer diseases.
How Beta 1,3/1,6 Glucan Nutritionally Fights Back Through the Immune Response Against Cancer and Aids in Chemotherapy
Effectiveness
The most common form of cancer is carcinoma, which originates in the skin, or in the glandular tissue such as the
breast or prostate gland. Another form of cancer, sarcoma, affects connective and supportive tissue such as bone,
muscle, cartilage and fat. Still another type are melanomas which are skin cancers. Lymphomas affect the lymphatic
system, while leukemias are cancers of the blood-forming organs.
The inability of the immune system to first recognize and then to appropriately respond to cancer tumors is a major
contributing factor to the ability of the disease to multiply and spread before recognition by the body.
Good news!
The immune response can be potentiated to more ably recognize the cancer attempting to hide in normal cells by
a naturally occurring biomolecule named Beta 1,3/1,6 glucan. A particularly potent immune potentiator is an insoluble
particulate Beta 1,3/1,6 glucan extracted and purified from Baker's yeast (no harmful yeast proteins remain that
cause an allergic reaction). Beta glucan is a non-toxic nutritional biomolecule classified G.R.A.S. by the FDA,
that significantly potentiates the macrophage, the large white immune cell; increasing its ability to recognize
cancerous cells, particularly as we age.
A Macrophage
According to research by Peter Mansell, Donald Carrow, M.D., Nicholas DiLuzio, D.L. Williams, M.L. Patchen and
others at Harvard, Baylor, Tulane, the Armed Services Radiobiology Research Institute and a multitude of other
scientific research centers, Beta glucan extracted from yeast cell wall enhances immune system awareness of the
cancerous cells and nutritionally aids in control. When potentiated by Beta 1,3/1,6 glucan, the immune alarm to
activate the entire immune response is sounded against the cancer, enabling the macrophages to attack the cancerous
cells with enhanced cytotoxic granules (toxic chemicals) that kill the cancer cell and prevent further multiplication
and spreading. Results have been particularly dramatic in breast, sarcoma and melanoma cancers.
The research demonstrates Beta 1,3/1,6 glucan, particularly in small particle sizes (microparticulate vs globular)
for better absorption and more rapid response, increases protection of the immune cells from the damage of radiation
treatments and then, after treatments, enhances recovery of platelets and white immune cells. The macrophage is
also enhanced to more ably and rapidly remove the toxic debris (phagocytosis) created by radiation and chemotherapy
in the body, thus reducing or eliminating the negative side effects such as nausea, hair loss, inability to sleep
and skin radiation injury.
In a Research Summary Report issued in 2001 by The University of Nevada School of Medicine and Nutritional Supply
Corporation it was found, "MPG Glucan has been shown to enhance the envelopment and digestion (phagocytosis)
of pathogenic microorganisms that cause infectious disease. The Beta-1,3/1-6 glucans additionally enhance the ability
of Macrophages, one of the most important immune cells in the immune system, to kill tumor cells. Laboratory studies
have revealed the new MPG Glucan is significantly effective at activating Macrophages, and via the Macrophages,
in turn the entire immune cascade including T-Cells and B-Cells."
Beta 1,3/1,6 glucan is most effective in nonaggregated, microparticulate form additionally purified in a patent-pending
proprietary process to provide enhanced potentiation of the macrophage immune cell with minimum amounts. Science
demonstrates particulate Beta glucan can nutritionally enable your immune response to fight back against cancer
invasion, reduce or eliminate the negative side effects of many treatments including chemotherapy and radiation
and, as an adjuvant, make chemotherapy treatments more effective than acting alone.
A nonaggregated microparticulate Beta glucan containing 10 mg per capsule (U.S. Patented MPG Beta glucan), with
potent nutritional phagocytic potentiation capabilities and the ability to increase natural production of TNF Alpha
(tumor necrosis factor - necrosis meaning "killing") in the immune cells, is the nutritional oral supplement
ingredient suggested.
Cancer affects us all and we must now utilize all available science to provide answers. Nature has provided Beta
glucan; science has demonstrated the benefits; now we must begin using this incredible biomolecule for nutritionally
potentiating the immune response not only to fight cancer, but the legion of pathogens that attempt to rob us of
good health daily. Reprinted by permission of Immunition Reports Research Notes to Report: (Entire transcripts
of the referenced research are available through PubMed) Cancer - Carcinoma of the Breast: Mansell P.W.A., Ichinose
H., Reed R.J., Krements E.T., McNamee R.B., Di Luzio N.R.; "Macrophage-mediated Destruction of Human Malignant
Cells in Vitro". Journal of National Cancer Institute; 54: 571-580. 1975.
Quote: "The initial 9 patients studied had malignant carcinoma of the breast. Control and experimental
lesions were injected; subsequently biopsies were performed at varying intervals for histologic evaluation. Always
when glucan or glucan and RF fraction were administered intra-lesionally, the size of the lesion was strikingly
reduced in as short a period as 5 days. In small lesions, resolution was complete, whereas in large lesions, resolutions
was partial." Cancer - Melanoma: DiLuzio N.R. Williams D.L. et al, "Comparative evaluation of the tumor
inhibitory and antibacterial activity of solubilized and particulate glucan," Recent Results Cancer Res 75:165-172.
1980.*
Quote: "Intravenous administration of soluble or particulate glucan resulted in significant reduction
in the growth of a syngeneic anaplastic mammary carcinoma and melanoma B16 and enhanced survival." Cancer
- Sarcoma and Melanoma: Williams DL, et al, "Therapeutic efficacy of glucan in a murine model of hepatic metastatic
disease," Hepatology 5(2):198-206. Mar 1985.*
Quote: ".coincubation of particulate glucan with diverse populations of normal or tumor cells in vitro
indicated that glucan exerted a direct cytostatic effect on sarcoma and melanoma cells and, in contrast, had a
proliferative effect on normal spleen and bone marrow cells." Cancer : Carrow, D.J.; "Beta-1,3-glucan
as a Primary Immune Activator," Townsend Letter; June 1996.
Quote: "Over the past 11 months I have been able to convince five out of eight breast cancer patients
who were undergoing radiation therapy, to consume one capsule of beta 1,3/1,6 glucan (NSC-24 3 mg) three times
per day. To date, I have observed that none of the patients using NSC-24 have suffered from any type of radiation
injury to the skin, while the three patients who chose not to use NSC-24 all show signs of extensive radiation
damage to the skin." Hemopoietic Stimulation: Patchen M.L., McVittie T.J.; Temporal Response of Murine Pluripotent
Stem Cells and Myeloid and Erythroid Progenitor Cells to Low-dose Glucan Treatment. Acta Hemat; 70:281-288. Experimental
Hematology Dept, Armed Forces Radiobiology Research Insti, Bethesda, MD. 1983.
Quote: "Clearly, there are numerous possible uses for an agent such as glucan, which is a potent stimulator
of hemopoietic [formation of blood cells] activity. Currently, we [U.S. Armed Services] are using glucan to enhance
hemopoietic proliferation in conjunction with hemopoietic injury induced by radiation." Platelet and White
Blood Cell Recovery: Pachen ML, MacVittie TJ, "Comparative effects of soluble and particulate glucans on survival
in irradiated mice," J Biol Response Mod 5(1):45-60. Experimental Hematology Dept, Armed Forces Radiobiology
Research Inst, Bethesda, MD. Feb 1986.
Quote: "Both glucan-P and glucan-F enhanced the recovery of peripheral blood white cell numbers, platelet
numbers, and hematocrit values. In addition, both agents increased endogenous pluripotent hemopoietic stem cell
numbers in sublethally irradiated mice."
T97-5 Judith Foulke (202) 205-4144 January 21, 1997 Broadcast Media (301) 827-3434 Consumer Hotline (800) 532-4440
FDA ALLOWS WHOLE OAT FOODS TO MAKE HEALTH CLAIM ON REDUCING THE RISK OF HEART DISEASE
[Editor's Note: You would have to eat 6 bowls of Quaker Oats to get the same anount of beta glucan as contained
in a single tablet of Young Again's Beta Glucan]
FDA will display at the Federal Register a final rule allow- ing health claims on the labels of foods containing
soluble fiber from whole oats (rolled oats, oat bran and oat flour) noting that these foods, as part of a diet
low in saturated fat and choles- terol, may reduce the risk of heart disease. The following may be used to answer
questions. FDA regulates health claims on food labels under provisions of the Nutrition Labeling and Education
Act of 1990 to ensure that claims are accurate and not misleading to consumers. The law allows the agency to authorize
a health claim only if there is significant scientific agreement that the claim is true. In allowing this health
claim, FDA concluded that the beta- glucan soluble fiber of whole oats is the primary component responsible for
the total and LDL blood cholesterol-lowering effects of diets that contain these whole oat-containing foods at
appropriate levels. This conclusion is based on review of scientific evidence indicating a relationship between
the soluble fiber in these whole oat-containing foods and a reduction in the risk of coronary heart disease. Food
products eligible to bear the health claim include oat bran and rolled oats, such as oatmeal, and whole oat flour.
Oat bran and rolled oats were the two food products named in a petition submitted by The Quaker Oats Company in
March 1995. FDA added whole oat flour to this final rule in response to data provided in comments following the
agency's publication of the proposed rule on January 4, 1996. The data submitted showed that whole oat flour is
nutritionally equivalent to rolled oats and, more importantly, has similar effects on serum lipids. In the final
rule, FDA acknowledges that sources of beta- glucan soluble fiber other than from whole oats, and certain soluble
fibers other than beta-glucan, are also likely to affect blood lipid levels. However, FDA must await evidence on
these other sources before making a judgment on their effects. To qualify for the health claim, the whole oat-containing
food must provide at least 0.75 grams of soluble fiber per serving. The amount of soluble fiber needed for an effect
on cholesterol levels is about 3 grams per day. Adding whole oat flour to the list of substances eligible to be
the subject of a claim means that many products will qualify for the claim, thus making it possible that oat-containing
products could be consumed as many as 4 times a day. Examples of how the newly allowed health claim may be used
are: "Soluble fiber from foods such as oat bran, as part of a diet low in saturated fat and cholesterol, may
reduce the risk of heart disease." or "Diets low in saturated fat and cholesterol that include soluble
fiber from oatmeal may reduce the risk of heart disease." The words, "Diets low in saturated fat and
cholesterol" must be included in any such health claim because FDA concluded, after reviewing comments, that
consumers might otherwise be misled into thinking that eating a diet high in oats is all that is necessary to reduce
the risk of heart disease. The final rule will be published later this week in Federal Register.
Quaker Oats, the cereal manufacturer, has a wonderful website clearly explaining how
the abundant
beta glucan in oatmeal provides remarkable cholesterol lowering power. Please remember you would
have to eat 32 bowls of Quaker Oats to get the same amount of beta glucan you get in one of our 200 mg tablets.
How Beta Glucan Work How Oats Work Quaker Oats.com